Dry Eye Clinical Studies

Operating mechanism of dry eye treatment with IRPL®

Quantified and cumulative efficacy

All the studies conducted showed improvement in the quality of meibum but also in the compression of the meibomian glands. This improvement will last: About a week after the initial treatment. Two to three weeks after the second. Between 6 months to 3 years after the third session. The effect is cumulative.

Notes: The total score of the 10 single symptoms were defined as the total symptom scores. (Dryness, Foreign body sensation, Itching, Burning, Visual Fatigue, Blurred Vision, Sensitivity to light, Watering, Secretion disturbance, Pain). *Compared to the baseline, the total symptom score significantly decreased at the time of D15, D45 and D75 (P<0.01). **Between the visits of D15 and D45, the total score continuously decreased (P<0.01), while between the visits of D45 and D75, no significant difference was observed (P=0.85).

Figure: Total symptom scores.

An instant improvement

The stimulation leads to the Meibomian glands returning to their normal function in a very short time (a couple of hours) following the treatment.

In the long run

The treatment effects last 6 months to 3 years after the 3rd to 4th sessions.

In 60% of cases, effects persist beyond 3 years after the treatment.

According to the Oxford scheme (0,I, II, III, IV), patients with lower grade (1 and 2) are “easy” candidates that go down from 1 to 2 grades after the first 3 sessions.

Scientifically Proven Efficacy Clinical Studies

2024 - Cristina-Patricia Pac

Intense Pulsed Light Therapy for Dry Eye Disease: Analyzing Temporal Changes in Tear Film Stability and Ocular Surface between IPL Sessions (DOI:10.3390/healthcare12111119)

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2020 New Zealand - Jennifer P. Craig

Randomised double-masked placebo-controlled trial of the cumulative treatment efficacy profile of intense pulsed light therapy for meibomian gland dysfunction (DOI: 10.1016/j.jtos.2020.01.003)

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2019 Italy - Luca Vigo

Ocular Surface Workup in Patients with Meibomian Gland Dysfunction Treated with Intense Regulated Pulsed Light (DOI: 10.3390/diagnostics9040147)

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2020 Turkey - Özgün Melike Gedar Totuk

Efficacy of Intense Pulsed Light Treatment for Moderate to Severe Acute Blepharitis or Blepharoconjunctivitis: A Retrospective Case Series (DOI: 10.4274/tjo.galenos.2020.28924)

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2017 Australia - Julie M Albietz, Katrina L Schmid

Intense pulsed light treatment and meibomian gland expression for moderate to advanced meibomian gland dysfunction

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2019 Milan, Italy - Carones Ophthalmology Center

Ocular Surface Workup in Patients with Meibomian Gland Dysfunction Treated with Intense Regulated Pulsed Light

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2015 New Zealand - Jennifer P. Craig, Chen, Y.-H., & Turnbull, P. R. K.

Prospective trial of intense pulsed light for the treatment of meibomian gland dysfunction

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2021 - S Egri

Efficacy of intense pulsed light therapy in the treatment of Meibomian gland dysfunction-related severe dry eye

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2016 - Jiang, X

Research Article Evaluation of the Safety and Effectiveness of Intense Pulsed Light in the Treatment of Meibomian Gland Dysfunction

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2016 France - Fondation A de Rothschild and Hôpital Bichat

Efficacy of Intense Regulated Pulsed Light Therapy

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2016 China - Official publication in "Journal of Ophthalmology" of Dr Li

Evaluation of the Safety and Effectiveness of Intense Pulsed Light

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2015 China - Peking Third University Hospital

Evaluation of the safety and effectiveness of the controlled discharge xenon flash lamp

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2013 France - Dr Malbrel

polychromatic pulsed light device for a dysfunction described as "dry eye"

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